No More Learning

Three million years ago, Australopithecus was bipedal and had feet like ours, although it probably still retreated up trees. But its brain, relative to its body size, was the same size as a chimpanzee's, and presumably the same as the shared ancestor with chimpanzees. Nobody knows whether the bipedal gait set up new selection pressures that encouraged the brain to grow, but Darwin's original arguments for simultaneous evolution can be adapted to make that plausible. Perhaps the enlargement of the brain had some- thing to do with language, but here nobody knows and disagreements abound. There is evidence that particular parts of the human brain are uniquely pre-wired to handle specific universals of language, although
49 the particular language spoken is, of course, locally learned.
Another twentieth-century idea which is probably important in human evolution, and which again would have intrigued Darwin, is neoteny: evo- lutionary infantilization. The axolotl, an amphibian living in a Mexican lake, looks just like the larva of a salamander, but it can reproduce, and has chopped off the adult, salamander stage of the life history. It is a sexually mature tadpole. Such neoteny has been suggested as a way in which a lineage can suddenly initiate an entirely new direction of evolution, at a stroke. Apes don't have a discrete larval stage like a tadpole or a caterpillar, but a more gradualistic version of neoteny can be discerned in human evolution. Juvenile chimpanzees resemble humans far more than adult chimpanzees do. Human evolution can be seen as infantilism. We are apes
50 that became sexually mature while still morphologically juvenile. If
humans could live for 200 years, would we finally 'grow up', drop on all fours and develop huge prognathous chimpanzee-like jaws? The possibility has not been lost on writers of ironic fiction, notably Aldous Huxley in After Many a Summer. He presumably learned about neoteny from his elder brother Julian, who was one of the pioneers of the idea and did amazing research on axolotls, injecting hormones to make them turn into salamanders never before seen.
Let me end by bringing together once again the two halves of Darwin's book. He went to town on sexual selection in The Descent of Man because he thought it was important in human evolution, and especially because he thought it was the key to understanding the
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differences among human races. Race, in Victorian times, was not the political and emotional minefield it is today, when one can give offence j by so much as mentioning the word. I shall tread carefully, but I cannot I ignore the topic because it is prominent in Darwin's book and especially germane to the unification of its two parts.
Darwin, like all Victorians, was intensely aware of the differences among humans but he also, more than most of his contemporaries, emphasized the fundamental unity of our species. In Descent he carefully considered, and decisively rejected, the idea, rather favoured in his own time, that different human races should be regarded as separate species. Today we know that, at the genetic level, our species is more than usually uniform. It has been said that there is more genetic variation among the chimpanzees of a small region of Africa than among the entire world population of humans (suggesting that we have been through a bottleneck in the past hundred thousand years or so). Moreover, the great majority of human genetic variation is to be found within races, not between them. This means that if you were to wipe out all human races except one, the I great majority of human genetic variance would be preserved. The variance between races is just a bit extra, stuck on the top of the greater quantity of variation within all races. It is for this reason that many geneticists advocate the complete abandonment of the concept of race.
At the same time - the paradox is similar to one recognized by Darwin - the superficially conspicuous features characteristic of local populations around the world seem very different. A Martian taxonomist who didn't know that all human races happily interbreed with one another, and didn't know that most of the underlying genetic variance in our species is shared by all races, might be tempted by our regional differences in skin colour, facial features, hair, body size and proportions to split us into more than one species. What is the resolution of the paradox? And why did such pronounced superficial differences evolve in different geographical areas, while most of the less conspicuous variation is dotted around across all geographical areas? Could Darwin have been right all along? Is sexual selection the answer to the paradox? The distinguished
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biologist Jared Diamond thinks so, and I am inclined to agree.
Utilitarian answers have been suggested to the question of the evolution of racial differences, and there may well be some truth in them. Dark skin may protect against skin cancer in the tropics, light skin admit beneficial rays in sun-starved latitudes where there is a danger of Vitamin D deficiency. Small stature probably is of benefit to hunters in dense forest, such as the pygmies of central Africa, and various independently evolved hunter gatherers of Amazon and South East Asian
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What sexual selection explains, better than natural selection, is diversity that seems arbitrary, even driven by aesthetic whim. Especially if the variation concerned is geographical. And also especially if some of the features concerned, for example beards and the distribution of body hair and subcutaneous fat deposits, differ between the sexes. Most people have no problem in accepting an analogue of sexual selection for culturally mediated fashions like headdresses, body paint, penis sheaths, ritual mutilations or ornamental clothes. Given that cultural differences such as those of language, religion, manners and customs certainly provide resistance to interbreeding and gene flow, I think it is entirely plausible that genetic differences between peoples of different regions, at least where superficial, externally prominent features are concerned, have evolved through sexual selection. Our species really does seem to have unusually conspicuous, even ostentatious, superficial differences between local populations, coupled with unusually low levels of overall genetic variation. This double circumstance carries, to my mind, the stamp of sexual selection.
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In this respect, human races seem a lot like breeds of dog, another
favourite topic of Darwin. Superficially, the domestic breeds of dogs are astonishingly varied, even more so than human races, yet the under- lying genetic differences are slight, and they are all clearly descended
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from wolves within the past few thousand years. Reproductive
isolation is today maintained by disciplined pedigree breeders, and the shapes and colours of the dogs themselves are steered through their rapid evolution by the whim of the human eye rather than the whim of female dogs. But the essential features of the situation, as Darwin realized, are similar to those of sexual selection.
In this, as in so much else, I suspect that Darwin was right. Sexual
selection really is a good candidate for explaining a great deal about the
unique evolution of our species. It may also be responsible for some
unique features of our species which are shared equally by all races, for
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example our enormous brain. Geoffrey Miller, in The Mating Mind, strongly developed precisely this case, and Darwin would have loved it
no less because Miller takes a Wallacean view of sexual selection. It is starting to look as though, despite initial appearances, Darwin really was right to bring together, in one volume, Selection in Relation to Sex and The Descent ofMan.
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Darwin Triumphant55 Darwinism as a Universal Truth
If we are visited by superior creatures from another star system - they will have to be superior if they are to get here at all - what common ground shall we find for discussion with them? Shall we overcome the barriers simply by learning one another's language, or will the subjects that interest our two cultures be so divergent as to preclude serious conversation? It seems unlikely that the star travellers will want to talk about many of our intellectual stocks-in-trade: about literary criticism or music, religion or politics. Shakespeare may mean nothing to those without human experiences and human emotions, and if they have a literature or an art these will probably be too alien to excite our sensi- bilities. To name two thinkers who have more than once been promoted as Darwin's equals, I rather doubt whether our visitors will have much interest in talking about Marx or Freud, other than perhaps as anthropological curiosities. We have no reason to suppose that these men's works are of more than local, parochial, human, earthly, post- Pleistocene (some would add European and male) significance.
Mathematics and physics are another matter. Our guests may find our level of sophistication quaintly low, but there will be common ground. We shall agree that certain questions about the universe are important, and we shall almost certainly agree on the answers to many of these questions. Conversation will flourish, even if most of the questions flow one way and most of the answers the other. If we discuss the histories of our respective cultures, our visitors will surely point with pride, however far back in time, to their equivalents of Einstein and Newton, of Planck and Heisenberg. But they won't point to an equivalent of Freud or Marx any more than we, visiting a hitherto undiscovered tribe in a remote forest clearing, would nominate our civilization's equiva- lent of the local rainmaker or gully-gully man. One does not have to disparage the local achievements of Freud and Marx on this planet to agree that their findings have no universality.
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? What about Darwin? Will our guests revere another Darwin as one of their greatest thinkers of all time? Shall we be able to have a serious conversation with them about evolution? I suggest that the answer is yes (unless, as a colleague suggests to me, their Darwin is on the expedi- tion and we are her Galapagos*). Darwin's achievement, like Einstein's, is universal and timeless, whereas that of Marx is parochial and ephemeral. That Darwin's question is universal, wherever there is life, is surely undeniable. The feature of living matter that most demands explanation is that it is almost unimaginably complicated in directions that convey a powerful illusion of deliberate design. Darwin's question, or rather the most fundamental and important of Darwin's many questions, is the question of how such complicated 'design' could come into being. All living creatures, everywhere in the universe and at any time in history, provoke this question. It is less obvious that Darwin's answer to the riddle - cumulative evolution by nonrandom survival of random hereditary changes - is universal. It is at first sight conceivable that Darwin's answer might be valid only parochially, only for the kind of life that happens to exist in our own little clearing in the universal
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forest. I have previously made the case that this is not so, that the
general form of Darwin's answer is not merely incidentally true of our kind of life but almost certainly true of all life, everywhere in the universe. Here, let me for the moment make the more modest claim that, at the very least, Darwin's bid for immortality is closer to the Einstein end of the spectrum than to the Marx end. Darwinism really matters in the universe.
When I was an undergraduate in the early nineteen sixties, we
were taught that although Darwin was an important figure in his own
time, modern neo-Darwinism was so much further advanced that it
hardly deserved the name Darwinism at all. My father's generation of
biologist undergraduates read, in an authoritative Short History of 57
. . . the struggle of living forms leading to natural selection by the survival of the fittest, is certainly far less emphasized by naturalists now than in the years that immediately followed the appearance of Darwin's book. At the time, however, it was an extremely stimulating suggestion.
And the generation of biologists before that could read, in the words of William Bateson, perhaps the dominant British geneticist of the time,
This is how my friend worded her suggestion. The joke was rather ruined by the political scruples of the original article's copy-editor, who changed 'her Galapagos' to 'his or her Galapagos'.
Biology , that
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We go to Darwin for his incomparable collection of facts [but] . . . for us he speaks no more with philosophical authority. We read his scheme of Evolution as we would those of Lucretius or Lamarck . . . The transformation of masses of populations by imperceptible steps guided by selection is, as most of us now see, so inapplicable to the fact that we can only marvel . . . at the want of
58 penetration displayed by the advocates of such a proposition.
And yet the editors of this volume can commission an article with the title 'Darwin Triumphant'. I do not normally like writing to titles that others have proposed, but I can accept this one without reservation. In the last quarter of the twentieth century, it seems to me that Darwin's standing among serious biologists (as opposed to nonbiologists influenced by religious preconceptions) is rightly as high as it has been at any time since his death. A similar story, of even more extreme eclipse in earlier years followed by triumphant recent rehabilitation, can be told of Darwin's 'other theory', that of sexual selection. *
It is only to be expected that, a century and a quarter on, the version
of his theory that we now have should be different from the original. Modern Darwinism is Darwinism plus Weismannism plus Fisherism plus Hamiltonism (arguably plus Kimuraism and a few other isms). But when I read Darwin himself, I am continually astonished at how modern
he sounds. Considering how utterly wrong he was on the all-important topic of genetics, he showed an uncanny gift for getting almost every- thing else right. Maybe we are neo-Darwinists today, but let us spell the neo with a very small n\ Our neo-Darwinism is very much in the spirit of Darwin himself. The changes that Darwin would see if he came back today are in most cases changes that, I venture to suggest, he would instantly approve and welcome as the elegant and obviously correct answers to riddles that troubled him in his own time. Upon learning that evolution is change in frequencies within a pool of particulate hereditary elements, he might even quote T. H. Huxley's alleged remark upon reading the Origin itself: 'How extremely stupid not to have thought of thatl't
*See 'Light Will Be Thrown' (pp. 63-77).
tOf the two stories about Huxley that have become chestnuts, I greatly prefer this to the one about his so-called 'debate' with the Bishop of Oxford, Sam Wilberforce. There is something admirably honest about Huxley's exasperation at not having thought of such a simple idea. I have long found it a complete mystery why it had to wait until the nineteenth century before anyone thought of it. Archimedes' and Newton's achievements seem, on the face of it, far more difficult. But the fact that nobody did think of natural selection before the nineteenth century clearly shows that I am wrong. As does the fact that so many people, even today, don't get it.
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? I referred to Darwin's gift for getting things right, but surely this can only mean right as we see it today. Shouldn't we be humble enough to admit that our right may be utterly wrong in the sight of future scientific generations? No, there are occasions when a generation's humility can be misplaced, not to say pedantic. We can now assert with confidence that the theory that the Earth moves round the Sun not only is right in our time but will be right in all future times even if flat- Earthism happens to become revived and universally accepted in some new dark age of human history. We cannot quite say that Darwinism is in the same unassailable class. Respectable opposition to it can still be mounted, and it can be seriously argued that the current high standing of Darwinism in educated minds may not last through all future generations. Darwin may be triumphant at the end of the twentieth century, but we must acknowledge the possibility that new facts may come to light which will force our successors of the twenty-first century to abandon Darwinism or modify it beyond recognition. But is there, perhaps, an essential core of Darwinism, a core that Darwin himself might have nominated as the irreducible heart of his theory, which we might set up as a candidate for discussion as potentially beyond the reach of factual refutation?
Core Darwinism, I shall suggest, is the minimal theory that evolution is guided in adaptively nonrandom directions by the nonrandom survival of small random hereditary changes. Note especially the words small and adaptively. Small implies that adaptive evolution is gradualistic, and we shall see why this must be so in a moment. Adaptive does not imply that all evolution is adaptive, only that core Darwinism's concern is limited to the part of evolution that is. There is no reason to assume
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that all evolutionary change is adaptive.
change is not adaptive, what is undeniable is that enough of evolution- ary change is adaptive to demand some kind of special explanation. It is the part of evolutionary change that is adaptive that Darwin so neatly explained. There could be any number of theories to explain non- adaptive evolution. Nonadaptive evolution may or may not be a real phenomenon on any particular planet (it probably is on ours, in the form of the large-scale incorporation of neutral mutations), but it is not a phenomenon that awakes in us an avid hunger for an explanation. Adaptations, especially complex adaptations, awake such a powerful hunger that they have traditionally provided one of the main motiva- tions for belief in a supernatural Creator. The problem of adaptation, therefore, really was a big problem, a problem worthy of the big solution that Darwin provided.
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But even if most evolutionary
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R. A. Fisher developed a case, which did not make any appeal to
particular facts, for the armchair deducibility of Mendelism.
It is a remarkable fact that had any thinker in the middle of the nineteenth century undertaken, as a piece of abstract and theoretical analysis, the task of constructing a particulate theory of inheritance, he would have been led, on the basis of a few very simple assumptions, to produce a system identical with the modern scheme of Mendelian or factorial inheritance.
Is there a similar statement that could be made about the inevitability of the core of Darwin's scheme of evolution by natural selection? Although Darwin and Wallace themselves were field naturalists who made extensive use of factual information to support their theory, can we now, with hindsight, argue that there should have been no need for the Beagle, no need for the Galapagos and Malay Archipelagos? Should any thinker, faced with the problem formulated in the right way, have been able to arrive at the solution - core Darwinism - without stirring from an armchair?
Part of core Darwinism arises almost automatically from the problem that it solves, if we express that problem in a particular way, as one of mathematical search. The problem is that of finding, in a gigantic mathe- matical space of all possible organisms, that tiny minority of organisms that is adapted to survive and reproduce in available environments. Again, Fisher put it with characteristically powerful clarity.
An organism is regarded as adapted to a particular situation, or to the totality of situations which constitute its environment, only in so far as we can imagine an assemblage of slightly different situations, or environments, to which the animal would on the whole be less well adapted; and equally only in so far as we can imagine an assemblage of slightly different organic forms, which would be less well adapted to that environment.
Imagine some nightmarish mathematical menagerie in which is found the all but infinitely large set of conceivable animal forms that could be cobbled together by randomly varying all the genes in all genomes in all possible combinations. For brevity, although it is not as precise a phrase as its mathematical tone leads one to think, I shall refer to this as the set of all possible animals (fortunately the argument I am developing is an order-of-magnitude argument which does not depend on numerical precision). Most of the members of this ill-favoured bestiary will never develop beyond the single-cell stage. Of the very few that manage to be born (or hatch, etc. ), most will be hideously mis- shapen monstrosities who will die early. The animals that actually exist,
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? or have ever existed, will be a tiny subset of the set of all possible animals. Incidentally, I use animal purely for convenience. By all means substitute plant or organism.
It is convenient to imagine the set of all possible animals as arrayed in a multidimensional genetic landscape. * Distance in this landscape means genetic distance, the number of genetic changes that would have to be made in order to transform one animal into another. It is not obvious how one would actually compute the genetic distance between any two animals (because not all animals have the same number of genetic loci); but again the argument does not rely upon precision, and it is intuitively obvious what it means, for instance, to say that the genetic distance between a rat and a hedgehog is larger than the genetic distance between a rat and a mouse. All that we are doing here is to place as well, in the same multidimensional system of axes, the very much larger set of animals that have never existed. We are including those that could never have survived even if they had come into existence, as well as those that might have survived if they had existed but as a matter of fact never came into existence.
Movement from one point in the landscape to another is mutation, interpreted in its broadest sense to include large-scale changes in the genetic system as well as point mutations at loci within existing genetic systems. In principle, by a sufficiently contrived piece of genetic engineering - artificial mutation - it is possible to move from any point in the landscape to any other. There exists a recipe for transforming the genome of a human into the genome of a hippo or into the genome of any other animal, actual or conceivable. It would normally be a very large recipe, involving changes to many of the genes, deletion of many genes, duplication of many genes, and radical reorganizations of the genetic system. Nevertheless, the recipe is in principle discoverable, and obeying it can be represented as equivalent to taking a single giant leap from one point to another in our mathematical space. In practice, viable mutations are normally relatively small steps in the landscape: children are only slightly different from their parents even if, in principle, they could be as different as a hippo is from a human. Evolution consists of step-by-step trajectories through the genetic space, not large leaps.
*I find this image, which is modified from the venerable American population geneticist Sewall Wright, a helpful way to think about evolution. I first made use of it in The Blind Watchmaker and gave it two chapters in Climbing Mount Improbable, where I called it a 'museum' of all possible animals. Museum is superficially better than landscape because it is three- dimensional, although actually, of course, we are usually dealing with many more than three dimensions. Daniel Dennett's version, in Darwin's Dangerous Idea, is a library, the vividly named 'Library of Mendel'.
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Evolution, in other words, is gradualistic. There is a general reason why this has to be so, a reason that I shall now develop.
Even without formal mathematical treatment, we can make some statistical statements about our landscape. First, in the landscape of all possible genetic combinations and the 'organisms' that they might generate, the proportion of viable organisms to nonviable organisms is very small. 'However many ways there may be of being alive, it is certain
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that there are vastly more ways of being dead. ' Second, taking any
given starting point in the landscape, however many ways there may be of being slightly different, it is obvious that there are vastly more ways of being very different. The number of near neighbours in the landscape may be large, but it is dwarfed by the number of distant neighbours. As we consider hyperspheres of ever increasing size, the number of progres- sively more distant genetic neighbours that the spheres envelop mounts as a power function and rapidly becomes for practical purposes infinite.
The statistical nature of this argument points up an irony in the claim, frequently made by lay opponents of evolution, that the theory of evolution violates the Second Law of thermodynamics, the law of increasing entropy or chaos* within any closed system. The truth is opposite. If anything appeared to violate the law (nothing really does), it would be the factst, not any particular explanation of those facts! The Darwinian explanation, indeed, is the only viable explanation we have for those facts that shows us how they could have come into being without violating the laws of physics. The law of increasing entropy is, in any case, subject to an interesting misunderstanding, which is worthy of a brief digression because it has helped to foster the mistaken claim that the idea of evolution violates the law.
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The Second Law originated in the theory of heat engines, but the
form of it that is relevant to the evolutionary argument can be stated in more general statistical terms. Entropy was characterized by the physicist Willard Gibbs as the 'mixed-upness' of a system. The law states that the total entropy of a system and its surroundings will not decrease. Left to itself, without work being contributed from outside, any closed system (life is not a closed system) will tend to become more mixed-up, less orderly. Homely analogies - or they may be more than analogies - abound. If there is not constant work being put in by a librarian, the orderly shelving of books in a library will suffer relentless degradation due to the inevitable if low probability that borrowers will return them
"Chaos here has its original and still colloquial meaning, not the technical meaning which it has recently acquired.
tAbout life's functional complexity or high 'information content'.
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? to the wrong shelf. We have to import a hard-working librarian into the system from outside, who, Maxwell's-Demon-like, methodically and energetically restores order to the shelves.
The common error to which I referred is to personify the Second Law: to invest the universe with an inner urge or drive towards chaos; a positive striving towards an ultimate nirvana of perfect disorder. It is partly this error that has led people to accept the foolish notion that evolution is a mysterious exception to the law. The error can most simply be exposed by reference to the library analogy. When we say that an unattended library tends to approach chaos as time proceeds, we do not mean that any particular state of the shelves is being approached, as though the library were striving towards a goal from afar. Quite the contrary. The number of possible ways of shelving the N books in a library can be calculated, and for any nontrivial library it is a very, very large number indeed. Of these ways, only one, or a very few, would be recognized by us as a state of order. That is all there is to it. Far from there being any mystical urge towards disorder, it is just that there are vastly more ways of being recognized as disorderly than of being recognized as orderly. So, if a system wanders anywhere in the space of all possible arrangements, it is almost certain - unless special, librarian-like steps are taken - that we shall perceive the change as an increase in disorder. In the present context of evolutionary biology, the particular kind of order that is relevant is adaptation, the state of being equipped to survive and reproduce.
Returning to the general argument in favour of gradualism, to find viable life forms in the space of all possible forms is like searching for a modest number of needles in an extremely large haystack. The chance of happening to land on one of the needles if we take a large random mutational leap to another place in our multidimensional haystack is very small indeed. But one thing we can say is that the starting point of any mutational leap has to be a viable organism - one of the rare and precious needles in the haystack. This is because only organisms good enough to survive to reproductive age can have offspring of any kind, including mutant offspring. Finding a viable body-form by random mutation may be like finding a needle in a haystack, but given that you have already found one viable body-form, it is certain that you can hugely increase your chances of finding another viable one if you search in the immediate neighbourhood rather than more distantly.
The same goes for finding an improved body-form. As we consider mutational leaps of decreasing magnitude, the absolute number of destinations decreases but the proportion of destinations that are
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improvements increases. Fisher gave an elegantly simple argument to ] show that this increase tends towards 50 per cent for mutational changes of very small magnitude. * His argument seems inescapable for any single dimension of variation considered on its own. Whether his precise conclusion (50 per cent) generalizes to the multidimensional case I shall not discuss, but the direction of the argument is surely indisputable. The larger the leap through genetic space, the lower is the probability that the resulting change will be viable, let alone an improve- ment. Gradualistic, step-by-step walking in the immediate vicinity of already discovered needles in the haystack seems to be the only way to find other and better needles. Adaptive evolution must in general be a crawl through genetic space, not a series of leaps.
But are there any special occasions when macromutations areI incorporated into evolution? Macromutations certainly occur in the laboratory,t Our theoretical considerations say only that viable macromutations should be exceedingly rare in comparison with viable micromutations. But even if the occasions when major saltations are viable and incorporated into evolution are exceedingly rare, even if they have occurred only once or twice in the whole history of a lineage from Precambrian to present, that is enough to transform the entire course of evolution. I find it plausible, for instance, that the invention of segmentation occurred in a single macromutational leap, once during the history of our own vertebrate ancestors and again once in the ancestry of arthropods and annelids. Once this had happened, in each of these two lineages, it changed the entire climate in which ordinary cumulative selection of micromutations went on. It must have resembled, indeed, a sudden catastrophic change in the external climate. Just as a lineage can, after appalling loss of life, recover and adapt to a catastro- phic change in the external climate, so a lineage might, by subsequent micromutational selection, adapt to the catastrophe of a macromutation as large as the first segmentation.
In the landscape of all possible animals, our segmentation example might look like this. A wild macromutational leap from a perfectly viable parent lands in a remote part of the haystack, far from any needle of viability. The first segmented animal is born: a freak; a monster none of whose detailed bodily features equip it to survive its new, segmented
*He used the analogy of perfecting the focus of a microscope. A very small movement of the objective lens has a 50 per cent chance of being in the right direction (which will improve the focus). A large movement is bound to make things worse (even if it was in the right direction, it will overshoot).
tMacromutations, or saltations, are mutations of large magnitude. A famous example in fruit flies is antennapedia. Mutant flies grow a leg where an antenna should be.
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? architecture. It should die. But by chance the leap in genetic space has coincided with a leap in geographical space. The segmented monster finds itself in a virgin part of the world where the living is easy and competition is light. What can happen when any ordinary animal finds itself in a strange place, a new continent, say, is that, although ill- adapted to the new conditions, it survives by the skin of its teeth. In the competition vacuum, its descendants survive for enough generations to adapt, by normal, cumulative natural selection of micromutations, to the alien conditions. So it might have been with our segmented monster. It survived by the skin of its teeth, and its descendants adapted, by ordinary micromutational cumulative selection, to the radically new conditions imposed by the macromutation. Though the macromutational leap landed far from any needle in the haystack, the competition vacuum enabled the monster's descendants subsequently to inch their way towards the nearest needle. As it turned out, when all the compensating evolution at other genetic loci had been completed, the body plan represented by that nearest needle eventually emerged as superior to the ancestral unsegmented body plan. The new local optimum, into whose vicinity the lineage wildly leapt, eventually turned out superior to the local optimum on which it had previously been trapped.
This is the kind of speculation in which we should indulge only as a last resort. The argument stands that only gradualistic, inch-by-inch walking through the genetic landscape is compatible with the sort of cumulative evolution that can build up complex and detailed adaptation. Even if segmentation, in our example, ended up as a superior body form, it began as a catastrophe that had to be weathered, just like a climatic or volcanic catastrophe in the external environment. It was gradualistic, cumulative selection that engineered the step-by- step recovery from the segmentation catastrophe, just as it engineers recoveries from external climatic catastrophes. Segmentation, according to the speculation I have just given, survived not because natural selection favoured it but because natural selection found compensatory ways of survival in spite of it. The fact that advantages in the segmented body plan eventually emerged is an irrelevant bonus. The segmented body plan was incorporated into evolution, but it may never have been favoured by natural selection.
But in any case gradualism is only a part of core Darwinism. A belief in the ubiquity of gradualistic evolution does not necessarily commit us to Darwinian natural selection as the steering mechanism guiding the search through genetic space. It is highly probable that Motoo Kimura
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is right to insist that most of the evolutionary steps taken through genetic space are unsteered steps. To a large extent the trajectory of small, gradualistic steps actually taken may constitute a random walk rather than a walk guided by selection. But this is irrelevant if - for the reasons given above - our concern is with adaptive evolution as opposed to evolutionary change per se. Kimura himself rightly insists* that his 'neutral theory is not antagonistic to the cherished view that evolution of form and function is guided by Darwinian selection'. Further,
the theory does not deny the role of natural selection in determining the course of adaptive evolution, but it assumes that only a minute fraction of DNA changes in evolution are adaptive in nature, while the great majority of phenotypically silent molecular substitutions exert no significant influence on survival and reproduction and drift randomly through the species.
The facts of adaptation compel us to the conclusion that evolutionary trajectories are not all random. There has to be some nonrandom guidance towards adaptive solutions because nonrandom is what adap- tive solutions precisely are. Neither random walk nor random saltation can do the trick on its own. But does the guiding mechanism necessarily have to be the Darwinian one of nonrandom survival of random spontaneous variation? The obvious alternative class of theory postulates some form of nonrandom, i. e. directed, variation.
Nonrandom, in this context, means directed towards adaptation. It
does not mean causeless. Mutations are, of course, caused by physical
events, for instance, cosmic ray bombardment. When we call them
random, we mean only that they are random with respect to adaptive
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improvement. It could be said, therefore, that, as a matter of logic,
some kind of theory of directed variation is the only alternative to natural selection as an explanation for adaptation. Obviously, combinations of the two kinds of theory are possible.
The theory nowadays attributed to Lamarck is typical of a theory of directed variation. It is normally expressed as two main principles. First, organisms improve during their own lifetime by means of the principle of use and disuse; muscles that are exercised as the animal strives for a
? 'Insists' may be putting it a bit strongly. Now that Professor Kimura is dead, the rather endearing story told by John Maynard Smith can be included. It is true that Kimura's book includes the statement that natural selection must be involved in adaptive evolution but, according to Maynard Smith, Kimura could not bear to write the sentence himself and he asked his friend, the distinguished American geneticist James Crow, to write it for him. The book is M . Kimura, The Neutral Theory of Molecular Evolution (Cambridge, Cambridge University Press, 1983).
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? particular kind of food enlarge, for instance, and the animal is con- sequently better equipped to procure that food in the future. Second, acquired characteristics - in this case acquired improvements due to use - are inherited so, as the generations go by, the lineage improves. Arguments offered against Lamarckian theories are usually factual. Acquired characteristics are not, as a matter of fact, inherited. The implication, often made explicit, is that if only they were inherited,
64 Lamarckism would be a tenable theory of evolution. Ernst Mayr, for
instance, wrote,
Accepting his premises, Lamarck's theory was as legitimate a theory of adaptation as that of Darwin. Unfortunately, these premises turned out to be invalid.
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Francis Crick showed an awareness of the possibility that general a
priori arguments might be given, when he wrote,
As far as I know, no one has given general theoretical reasons why such a
mechanism must be less efficient than natural selection.
I have since offered two such reasons, following an argument that the
inheritance of acquired characteristics is in principle incompatible with 66
embryology as we know it.
First, acquired improvements could in principle be inherited only if
embryology were preformationistic rather than epigenetic. Preformationistic embryology is blueprint embryology. The alternative is recipe, or computer-program, embryology. The important point about blueprint embryology is that it is reversible. If you have a house, you can, by following simple rules, reconstruct its blueprint. But if you have a cake, there is no set of simple rules that enables you to reconstruct its recipe.
All living things on this planet grow by recipe embryology, not blue- print embryology. The rules of development work only in the forward direction, like the rules in a recipe or computer program. You cannot, by inspecting an animal, reconstruct its genes. Acquired characteristics are attributes of the animal. In order for them to be inherited, the animal would have to be scanned and its attributes reverse-transcribed into the genes. There may be planets whose animals develop by blue- print embryology. If so, acquired characteristics might there be inherited. This argument says that if you want to find a Lamarckian form of life, don't bother to look on any planet whose life forms develop by epigenesis rather than preformationism. I have an intuitive hunch that there may be a general, a priori argument against preformationistic, blueprint embryology, but I have not developed it yet.
DARWIN TRIUMPHANT
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Second, most acquired characteristics are not improvements. There is no general reason why they should be, and use and disuse does not really help here. Indeed, by analogy with wear and tear on machines, we might expect use and disuse to be positively counterproductive. If acquired characteristics were indiscriminately inherited, organisms would be walk- ing museums of ancestral decrepitude, pock-marked from ancestral plagues, limping relics of ancestral misfortune. How is the organism supposed to 'know' how to respond to the environment in such a way as to improve itself? If there is a minority of acquired characteristics that are improvements, the organism would have to have some way of selecting these to pass on to the next generation, avoiding the much more numerous acquired characteristics that are deleterious. Selecting, here, really means that some form of Darwinian process must be smuggled in. Lamarckism cannot work unless it has a Darwinian underpinning.
Third, even if there were some means of choosing which acquired characteristics should be inherited, which discarded at the current generation, the principle of use and disuse is not powerful enough to fashion adaptations as subtle and intricate as we know them to be. A human eye, for instance, works well because of countless pernickety adjustments of detail. Natural selection can fine-tune these adjustments because any improvement, however slight and however deeply buried in internal architecture, can have a direct effect upon survival and reproduction. The principle of use and disuse, on the other hand, is in principle incapable of such fine-tuning. This is because it relies upon the coarse and crude rule that the more an animal uses a bit of itself, the bigger that bit ought to be. Such a rule might tune the blacksmith's arms to his trade, or the giraffe's neck to the tall trees. But it could hardly be responsible for improving the lucidity of a lens or the reaction time of an iris diaphragm. The correlation between use and size is too loose to be responsible for fine-grained adaptation.
I shall refer to these three arguments as the 'Universal Darwinism' arguments. I am confident that they are arguments of the kind that Crick was calling for, although whether he or anyone else accepts these three particular arguments is another matter. If they are correct, the case for Darwinism, in its most general form, is enormously strengthened.
I suspect that other armchair arguments about the nature of life all over the universe, more powerful and watertight than mine, are waiting to be discovered by those better equipped than I am. But I cannot forget that Darwin's own triumph, for all that it could have been launched from any armchair in the universe, was in fact the spin-off of a five-year circumnavigation of this particular planet.
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? 1
MM ? "%#
The 'Information Challenge'
In September 1997,1 allowed an Australian film crew into my house in Oxford without realizing that their purpose was creationist propaganda. In the course of a suspiciously amateurish interview, they issued a truculent challenge to me to 'give an example of a genetic mutation or an evolutionary process which can be seen to increase the information in the genome'. It is the kind of question only a creationist would ask in that way, and it was at this point I tumbled to the fact that I had been duped into granting an interview to creationists - a thing I normally don't do, for good reasons. * In my anger I refused to discuss the question further, and told them to stop the camera. However, I eventually with- drew my peremptory termination of the interview, because they pleaded with me that they had come all the way from Australia specifically in order to interview me. Even if this was a considerable exaggeration, it seemed, on reflection, ungenerous to tear up the legal release form and throw them out. I therefore relented.
My generosity was rewarded in a fashion that anyone familiar with fundamentalist tactics might have predicted. When I eventually saw the film a year later,f I found that it had been edited to give the false impression that I was incapable of answering the question about information content. ^ In fairness, this may not have been quite as intentionally deceitful as it sounds. You have to understand that these people really believe that their question cannot be answered! Pathetic as it sounds, their entire journey from Australia seems to have been a quest to film an evolutionist failing to answer it.
*See 'Unfinished Correspondence with a Darwinian Heavyweight' (pp. 218-22).
tThe producers never deigned to send me a copy: I completely forgot about it until an American colleague called it to my attention.
JSee Barry Williams, 'Creationist deception exposed', the Skeptic 18 (1998), 3, pp. 7-10, for an account of how my long pause (trying to decide whether to throw them out) was made to look like hesitant inability to answer the question, followed by an apparently evasive answer to a completely different question.
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With hindsight - given that I had been suckered into admitting them into my house in the first place - it might have been wiser simply to answer the question. But I like to be understood whenever I open my mouth - 1 have a horror of blinding people with science - and this was not a question that could be answered in a soundbite. First you have to explain the technical meaning of 'information'. Then the relevance to evolution, too, is complicated - not really difficult but it takes time. Rather than engage in further recriminations and disputes about exactly what happened at the time of the interview, I shall try to redress the matter now in constructive fashion by answering the original question, the 'Information Challenge', at adequate length - the sort of length you can achieve in a proper article.
The technical definition of 'information' was introduced by the American engineer Claude Shannon in 1948. An employee of the Bell Telephone Company, Shannon was concerned to measure information as an economic commodity. It is costly to send messages along a telephone line. Much of what passes in a message is not information: it is redundant. You could save money by recoding the message to remove the redundancy. Redundancy was a second technical term introduced by Shannon, as the inverse of information. Both definitions are mathe- matical, but we can convey Shannon's intuitive meaning in words. * Redundancy is any part of a message that is not informative, either because the recipient already knows it (is not surprised by it) or because it duplicates other parts of the message. In the sentence 'Rover is a poodle dog', the word 'dog' is redundant because 'poodle' already tells us that Rover is a dog. An economical telegram would omit it, thereby increasing the informative proportion of the message. 'Arr JFK Fri pm pis mt BA Cncrd fit' carries the same information as the much longer, but more redundant, 'I'll be arriving at John F Kennedy airport on Friday evening; please meet the British Airways Concorde flight'. Obviously the brief, telegraphic message is cheaper to send (although the recipient may have to work harder to decipher it - redundancy has its virtues if we forget economics). Shannon wanted to find a mathe- matical way to capture the idea that any message could be broken into
*It is important not to blame Shannon for my verbal and intuitive way of expressing what I think of as the essence of his idea. Mathematical readers should go straight to the original, C. Shannon and W. Weaver, The Mathematical Theory of Communication (University of Illinois Press, 1949). Claude Shannon, by the way, had an imaginative sense of humour. He once built a box with a single switch on the outside. If you threw the switch, the lid of the box slowly opened, a mechanical hand appeared, reached down and switched off the box. It then put itself away and the lid closed. As Arthur C. Clarke said, 'There is something unspeakably sinister about a machine that does nothing - absolutely nothing - except switch itself off. '
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? the information (which is worth paying for), the redundancy (which can, with economic advantage, be deleted from the message because, in effect, it can be reconstructed by the recipient) and the noise (which is just random rubbish).
'It rained in Oxford every day this week' carries relatively little information, because the receiver is not surprised by it. On the other hand, 'It rained in the Sahara desert every day this week' would be a message with high information content, well worth paying extra to send. Shannon wanted to capture this sense of information content as 'surprise value'. It is related to the other sense - 'that which is not duplicated in other parts of the message' - because repetitions lose their power to surprise. Note that Shannon's definition of the quantity of information is independent of whether it is true. The measure he came up with was ingenious and intuitively satisfying. Let's estimate, he suggested, the receiver's ignorance or uncertainty beforereceiving the message, and then compare it with the receiver's remaining ignorance after receiving the message.